Anti-CEA

Product Category Product Catalog>>Primary Antibody>>Primary Antibody

Product Code by-0719R
English name Anti CEA
Chinese name: carcinoembryonic antigen antibody
alias
CEA ; Carcinoembryonic antigen; Carcinoembryonic antigen related cell adhesion molecule 5;
CD66e; CD66e antigen; CEA; CEACAM5; DKFZp781M2392; Meconium antigen 100; Ceacam3; Cear; Cgm1;
Cgm4; CGM4AA; MGC114355; RATCEAA; RATCGM4AA.

Product price: 0.1ml/100 μ g/780 yuan 0.2ml/200 μ g/1100 yuan 1mg/1mg/3260 yuan

Concentration 1mg/1ml
Antibody source Rabbit
Clone type polyclonal
Cross reactivity hu
Product type: primary antibody

Research field: Tumor cell type markers
Protein molecular weight predicted: 150-200kDa
Characteristic: Lyophilized or Liquid
免疫原 KLH conjugated synthetic peptide derived from human CEA N-terminus
Subtype IgG

Affinity purified by Protein A purification method
储存液0.01 M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Product Application

WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500
Flow-Cyt=1:100-500 IF=1:100-500
(Paraffin sections require antigen repair) not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Storage conditions

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody
is stable at room temperature for at least one month and for greater than a year when kept
at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody
is stable for at least two weeks at 2-4 °C.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic
or diagnostic applications.

Anti-CEA
Product Introduction

CEA-related cell adhesion molecules （CEACAM） belong to the carcinoembryonic antigen （CEA）
family. It consists of seven CEACAM （CEACAM 1, CEACAM 3-CEACAM 8） and 11 pregnancy-specific
glyco-protein （PSG 1-PSG 11） members. The CEA family proteins belong to the immunoglobulin
（Ig） superfamily and are composed of one Ig variable-like （IgV） and a varying number （0-6）
of Ig constant-like （IgC） domains. CEACAM molecules are membrane-bound either via a
transmembrane domain or a glycosyl phosphatidyl inositol （GPI） anchor. CEACAM molecules are
differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/ CEACAM
5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The
function of CEACAM family members varies widely: they function as cell adhesion molecules,
tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of
Neisseria species and other bacteria.
Subcellular Location : Cell membrane; Lipid-anchor, GPI-anchor.
Tissue Specificity : Found in adenocarcinomas of endodermally derived digestive system
epithelium and fetal colon.
Similarity : Belongs to the immunoglobulin superfamily. CEA family.
Contains 7 Ig-like （immunoglobulin-like） domains.
Subunit : Homodimer.

CEA is an embryonic antigen mainly present in the epithelial tissue of the fetal digestive tract, pancreas, and liver cancer. CEA widely exists in various epithelial tumors
The positive distribution of CEA in tumors, especially gastrointestinal malignancies, is related to the malignancy of the tumor. CEA, like EMA, can act as an epithelial malignancy
An important marker of sexual tumors.

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