【Product Name】 ：SBF simulated body fluid (1.5X, sterile)

【Product Specifications ：500ml

【Storage conditions】 ：2～8℃ 保存

【Validity period】 ：6 months

【Product Introduction】 ：

Simulated bodily fluids are usually abbreviated asSBForKokuboSolution.KokuboHe and his colleagues developed a non cellular simulated body fluid with an inorganic ion concentration similar to that of human extracellular fluid, with the aim of replicating the formation of hydroxyapatite on bioactive materials in vitro. This solution can not only be used to evaluate the in vitro biological activity of artificial materials, but also to coat various materials with hydroxyapatite under biomimetic conditions.

This product is only for scientific research experiments and is not intended for any other purposes!

【main ingredients】 ：

Mainly composed of sodium chloride, potassium chloride, dipotassium hydrogen phosphate, magnesium chloride, calcium chlorideTrisComposition of sodium bicarbonate, etc

【Background introduction】 ：

With the continuous development of medicine and manufacturing technology, various biomaterials (such as artificial bones, artificial teeth, etc.) used in plastic and restorative surgery are emerging and constantly improving. However, all such artificially synthesized materials will inevitably face the same problem from research and development to practical application----Whether it can exist stably in the human body without causing harm to the human body, animal experiments are one of the most commonly used methods by researchers to prove the safety and reliability of materials. However, animal experiments still have shortcomings such as high technical content, high cost, inability to flexibly sample and observe, and long experimental cycles. Therefore, simple and feasible in vitro simulation experiments have emerged and are constantly being used.

SBF is currently the most commonly used solution for in vitro simulations and serves as the basis for conducting in vitro simulation experiments. It was designed by Japanese scholars Tadashi KoKuBo et al. using the ion concentration of human plasma as a template to test the biological activity of the material. The principle of action of SBF is that artificially synthesized materials can be connected to bones by forming a bone like apatite layer on the surface after implantation into the human body; Similarly, artificial materials can also form hydroxyapatite in SBF with ion concentrations similar to human plasma, indicating that the material has biological activity. In recent years, SBF has been continuously adjusted, with most focusing on changes in ion concentrations.

【Precautions】 ：

1SBF simulates body fluids as sterile solutions. If sterile operation is required, attention should be paid to sterile operation.

2SBF simulated body fluids should be stored in a sealed environment at 4 ℃ to avoid affecting their efficiency.

3For safety and health reasons, it is recommended to wear lab coats and disposable gloves during operation.